‘Self-Spreading’ Vaccines Pose Multiple Risks to Society — Including the End of Informed Consent
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Proponents argue self-disseminating vaccines could mean they no
longer have to run complex mass vaccination programs. Critics say the
vaccines pose many health risks and would also spell the end of informed
consent.
In October 2019, the Johns Hopkins University Center for Health Security co-sponsored the “pandemic exercise,” Event 201.
A little more than a year later, when the Event 201 scenario morphed
from “hypothetical” to concrete, it became clear that sponsors of the
event intended to see the majority of the world vaccinated against
COVID-19.
Accomplishing this goal is a “monumental challenge,” however. In the U.S., more than one-third (38% to 45%) of adults continue to decline the unlicensed, Emergency Use Authorization injections, despite a marketing blitz that has included both carrots (ranging from the chance to win cash payments to a free order of fries) and sticks (such as nasty calls to “get personal” and “shun” the unvaccinated).
Although some of the uninjected tell pollsters they plan to
eventually get the vaccine, a solid minority remains committed to never
doing so. The same pattern appears to hold true globally: Roughly one-third of adults worldwide said they will not take a COVID shot.
While social and behavioral science researchers apply “soft science” techniques in an attempt to maneuver vaccine confidence
into more acquiescent territory, bench scientists have a different
option potentially waiting in the wings — genetically engineered
vaccines that “move through populations in the same way as communicable diseases,” spreading on their own “from host to host.”
Not mainstream (yet)
In theory, self-spreading vaccines (also referred to as self-disseminating or autonomous) can be designed to be either transferable (“restricted to a single round of transmission”) or transmissible (“capable of indefinite transmission).”
Vaccine scientists concede transmissible vaccines “are still not mainstream, but the revolution in genome engineering poises them to become so.”
The makers of self-disseminating vaccines use recombinant vector technology to build genetic material from a target pathogen onto the “chassis” of a viral vector deemed “benign,” “innocuous” or “avirulent.” This is similar to the viral vector approach used to produce the Johnson & Johnson and AstraZeneca COVID vaccines.
For Johns Hopkins, the appeal of vaccines that are intentionally
engineered to be self-disseminating seems obvious. The university’s
Center for Health Security made its case explicit in a 2018 report,
“Technologies to Address Global Catastrophic Biological Risks.” The
report stated, “These vaccines could dramatically increase vaccine
coverage in human … populations without requiring each individual to be
inoculated.”
Further spelling out the utilitarian implications of
self-disseminating vaccines, the report’s authors stated, “only a small
number of vaccinated individuals would be required to confer protection
to a larger susceptible population, thus eliminating the need for mass
vaccination operations.”
From a programmatic standpoint, this strategy would have the advantage of being “cheaper than vaccinating everyone by hand.” Perhaps even more significantly, however, it would override one of the “thorny ethical questions” that mass vaccination programs routinely wrestle with: informed consent.
As the university’s Center for Health Security briefly acknowledged
in its report, self-disseminating vaccines would essentially make it
impossible for “those to whom the vaccine subsequently spreads” to
provide informed consent at all.
Blame the animals
Writing in 2020 in Nature Ecology & Evolution, researchers observed that viral zoonoses (diseases theorized to jump from animals to humans) have become an entrenched part of the “global mindset” and a central element of the pandemic-obsessed global health zeitgeist.
Despite SARS-CoV-2’s unproven zoonotic origins (cast into doubt by figures such as Robert Redfield, former director of the Centers for Disease Control and Prevention), the past year’s coronavirus hype has helped reinforce
the popular perception that wildlife populations represent a menacing
cauldron of latent viral threats — requiring only the right set of
circumstances to spring into humanity-endangering action.
Parlaying the COVID moment into a convenient scientific opportunity, researchers suggest
that the purported “failure to contain the SARS-Cov-2 pandemic”
furnishes a rationale for accelerating the rollout of self-disseminating
vaccines. As some journalists have phrased
the question du jour, “Wouldn’t it be great if wild animals could be
inoculated against the various diseases they host so that those microbes
never get a chance to spread to humans?”
Transmissible-vaccine research also has ascended the list of funding priorities for government agencies like the Defense Advanced Research Projects Agency (DARPA) and the National Institutes of Health (NIH) and, reportedly, donors such as the Gates Foundation.
At least officially, the primary focus of self-spreading vaccine
research has thus far been on wildlife populations. Although the
practice of direct wildlife vaccination (for example, against rabies)
has been around since the 1960s, it is the longstanding efforts to
develop sterilizing vaccines in wildlife (euphemistically called “immunocontraception”), as well as recent advances in genetic engineering, that “have provided a foundation for transmissible-vaccine research.”
Researchers explain how the targeting of wildlife reservoirs is intended to work:
“The idea, essentially, is to vaccinate a small proportion of a
[wildlife] population through direct inoculation. These so-called
founders will then passively spread the vaccine to other animals they
encounter either by touch, sex, nursing, or breathing the same air.
Gradually, these interactions could build up population-level immunity.”
When put to the test by Spanish researchers in a limited field trial
in rabbits, about 50% of the unvaccinated rabbits developed antibodies
after being housed with vaccinated rabbits who had received a
transmissible vaccine either via injection or orally. When the
researchers assessed second-generation transmission
(that is, development of antibodies in another batch of rabbits moved
in with the first batch of unvaccinated rabbits), the transmission rate
was much lower (two of 24 rabbits).
What could possibly go wrong?
As the Johns Hopkins report made clear in 2018, there is no technical
reason why the self-spreading approach could not be applied to humans.
The authors admitted to “several big challenges,”
however, including the fact that autonomous vaccines (as mentioned
above) would render informed consent a moot point and would make it
impossible to screen individuals for contraindications such as
allergies.
According to Johns Hopkins and others, another major challenge is the “not insignificant risk of the vaccine virus reverting to wild-type virulence,” creating an opportunity for the vaccines to propagate disease rather than prevent it.
In fact, the world is already familiar with this phenomenon in the
form of oral polio vaccines. Though not “intentionally designed that
way,” oral polio vaccines are considered “a little bit transmissible” and are acknowledged to cause polio.
Hopkins’ researchers pointedly characterized the reversion challenge as “both a medical risk and a public perception risk.”
Another Catch-22 articulated in the university’s report is that while
reversion risks could perhaps be lessened by engineering the vaccines to
be more “weakly transmissible,” this could defeat the purpose of getting vaccines to “go” on their own.
On the other hand, the two scientists who are most strongly promoting
transmissible vaccines argue that “even … where reversion is frequent,
[their] performance will often substantially exceed that of conventional, directly administered vaccines.”
These same authors have also developed models suggesting that
starting the transmissible ball rolling with direct vaccination of newborns could be particularly impactful.
In September 2020, two researchers writing
in the Bulletin of the Atomic Scientists agreed that self-spreading
vaccines may have significant downsides and could “entail serious
risks,” particularly given that scientists lose control of their
creation once released. They noted, “While it may turn out to be
technically feasible to fight emerging infectious diseases … with
self-spreading viruses, and while the benefits may be significant, how
does one weigh those benefits against what may be even greater risks?”
They outlined several additional questions:
- Who makes the decisions about the “where and when” of the vaccines’ release?
- What happens when there are “unexpected outcomes” and “unintended
consequences” such as mutation, species-jumping or border-crossing?
About unintended consequences, the two authors added, “There always
are.”
- What about bioweapons and “dual use” risks — that is, using the
technology to “deliberately cause harm” rather than prevent disease?
Advances in pharmacogenomics, drug development and personalized medicine, the two noted, could enable “ultra-targeted biological warfare.”
On the latter point, the Bulletin authors drew readers’ attention to immunocontraception efforts in animals as well as an infamous example of “weaponized biology” against humans in apartheid-era South Africa, called Project Coast,
which sought — reportedly unsuccessfully — to develop an “infertility
‘vaccine’ to be used on black women without their knowledge.”
Other scientists have made an even more direct case against
transmissible vaccines, arguing the risks of autonomously spreading
vaccines do, in fact, “far outweigh
potential benefits.” Risks, in their view, include “the
unpredictability of mutations of the virus, the inability to safely test
at a large scale and the grave potential threat to biosecurity.”
Vaccine science: many unknowns
When measles, rather than COVID, was dominating the headlines a couple years ago, the unvaccinated were heavily scapegoated for apparent outbreaks. This non-evidence-based finger-pointing (used to usher in draconian new vaccine mandates), ignored the well-documented “phenomenon of measles infection spread by MMR
(live measles-mumps-rubella vaccine), which has been known about for
decades” and has resulted in “detectable measles infection in the vast
majority of those who receive it.”
The experimental Pfizer and Moderna COVID vaccines use new messenger RNA
(mRNA) technology rather than the traditional live-virus technology
featured in vaccines like the MMR, and thus, we are told, they cannot
produce the same type of “shedding.”
However, many unvaccinated individuals are reporting unusual symptoms
or illness after spending time in proximity to COVID-vaccinated
individuals. Pointing to Pfizer’s protocol acknowledging the possibility
of exposure via inhalation or skin contact with vaccinated individuals, concerned health professionals have raised the question of whether some novel form of shedding is occurring.
Some of the people raising these questions have pointed to the September 2020 article in the Bulletin of the Atomic Scientists, subtitled, “What could possibly go wrong?” By May 2021,
the Bulletin’s editors, apparently uncomfortable with the attention the
September article had attracted, were trying to distance themselves by
stating the Bulletin’s content was being misused to further conspiracy
theories about “highly effective and safe COVID-19 vaccines.”
Whether the COVID injections are “self-spreading” in any sense of the
word is a question that cannot currently be answered. However, there is
at least one plausible molecular mechanism that could explain the
observed vaccinated-to-unvaccinated “shedding” effects.
GreenMedInfo’s Sayer Ji explains that “horizontal information transfer
within biological systems [is] mediated by extracellular vesicles,
which include a virus-like phenomenon known as microvesicle shedding
and/or exosome-mediated transfer of nucleic acids.” Citing a 2017
peer-reviewed study on the “biology and biogenesis of shed microvesicles,” Ji states:
“[I]t is possible that [mRNA vaccines]
do, in fact, contribute to microvesicle shedding, which represents an
even greater, more persistent threat than live-cell vaccine shedding
when it comes to the persistent biological impact the vaccinated can
have on the unvaccinated.”
What is even more certain is that scientists themselves do not have
all the answers. Some may wish to believe in the possibility of simply
genetically engineering a vaccine “in ways that thwart its ability to evolve into something nasty.” But others note “the inevitability of evolutionary change resulting from [transmissible vaccines’] ability to self-replicate and generate extended chains of transmission.”
Techno-thriller author Michael Crichton predicted
in 2002 that with the advent of nanotechnology and other technological
innovations, the pace of evolutionary change was likely to be “extremely
rapid.” Crichton cautioned, “human beings have a poor record of
addressing the hazards of new technologies as they arrive.”
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Featured image is from Children’s Health Defense
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