Coronavirus study identifies ‘gain of function for efficient spread in humans’

https://www.express.co.uk/news/weird/1253135/coronavirus-genetically-engineered-bioweapon-wuhan-lab-leak-covid19-spt


Coronavirus study identifies ‘gain of function for efficient spread in humans’

CORONAVIRUS scientists have identified a "gain of function" in the virus, which has allowed for the "efficient spread in humans," a bombshell study revealed.

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Coronavirus: Expert explains 'respiratory infection’ symptoms

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COVID-19 has now infected nearly 120,000 people, killing more than 4,600 in the process in a devastating outbreak which has now been declared a pandemic. Italy has been placed on lockdown as the infection spreads through Europe at an alarming rate. A study released by Chinese scientists earlier this month found the origin of coronavirus could have come from the Wuhan Institute of Virology, a level four biosafety laboratory 12km from the epicentre of the outbreak.

Now, a new investigation, titled “Coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade,” suggests it is unlike anything seen before.

Published on ScienceDirect this month, the paper reads: “In 2019, a new coronavirus (2019-nCoV) infecting humans has emerged in Wuhan, China.

“Its genome has been sequenced and the genomic information promptly released. 

“Despite a high similarity with the genome sequence of SARS-CoV, we identified a peculiar furin-like cleavage site of the 2019-nCoV, lacking in the other SARS-like CoVs. 

Coronavirus has a gain of function for the efficient spread in humans

Coronavirus has a gain of function for the efficient spread in humans (Image: GETTY)

Italy has been put on lockdown

Italy has been put on lockdown (Image: GETTY)

For efficient spreading in the human population compared to other coronaviruses

Study

"In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.”

Furin is a "highly expressed" protein found in the lungs of humans that could have been used to activate a virus that previously could have only been passed between animals.

The experts believe this “peculiar furin” is an anomaly and could be used to “successfully exploit” enzymes that innate immunity in humans.

The paper goes on to explain how scientist have not seen anything like this in previous strains.

It adds: “Before the emergence of the 2019-nCoV, this important feature was not observed in other coronaviruses. 

READ MORE: Coronavirus: Experiment gone wrong? Two Wuhan lab leaks exposed by Chinese scientists

The virus originates in Wuhan

The virus originates in Wuhan (Image: GETTY)

“Strikingly, the 2019-nCoV sequence contains 12 additional nucleotides upstream of the single cleavage site.”

The paper suggests that this part of the DNA chain has evolved for “gain-of-function to the 2019-nCoV for efficient spreading in the human population compared to other coronaviruses".

It adds: “This possibly illustrates a convergent evolution pathway between unrelated CoVs.”

The medical definition for gain-of-function, also known as GOF, is a mutation that confers new or enhanced activity on a protein.

But, it can also involve genetic engineering.

According to the US National Library of Medicine, gain-of-function research, ofter simply referred to as GOF, “involves experimentation that aims or is expected to increase the transmissibility and/or virulence of pathogens.

“Such research, when conducted by responsible scientists, usually aims to improve understanding of disease-causing agents, their interaction with human hosts, and/or their potential to cause pandemics.

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The study suggests some developments in the virus

The study suggests some developments in the virus (Image: GETTY)

COVID-19 Has killed 4,600

COVID-19 Has killed 4,600 (Image: GETTY)

“Despite these important potential benefits, GOF research can pose risks regarding biosecurity and biosafety.”

In 2014 the administration of US President Barack Obama called for a “pause” on funding (and relevant research with existing US Government funding) of GOF experiments involving influenza, SARS, and MERS viruses in particular. 

In 2015, Ralph Baric, an infectious-disease researcher at the University of North Carolina at Chapel Hill published a study on his team’s efforts to engineer a virus with the surface protein of the SHC014 coronavirus, found in horseshoe bats in China, and the backbone of one that causes human-like severe acute respiratory syndrome (SARS) in mice. 

They found that the hybrid virus could infect human airway cells and caused disease in mice, according to the team’s results, which were published in Nature Magazine.

The results demonstrate the ability of the SHC014 surface protein to bind and infect human cells, validating concerns that this virus—or other coronaviruses found in bat species—may be capable of making the leap to people without first evolving in an intermediate host.

They also reignite a debate about whether that information justifies the risk of such work, known as gain-of-function research. 

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Correction 

This article was originally headlined "Coronavirus shock claim: Virus 'genetically engineered for efficient spread in humans' and examined a paper entitled  “Coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade" the article claimed the 'paper suggested that this part of the DNA chain has been tampered with for “gain-of-function to the 2019-nCoV for efficient spreading in the human population compared to other coronaviruses".' 

In addition, the article included an image captioned "Coronavirus may have been genetically engineered." The caption has been deleted. 

In fact, the study discussed the “functional consequences” of a “peculiar furin-like cleavage site”. It stated: “Despite a high similarity with the genome sequence of SARS-CoV, we identified a peculiar furin-like cleavage site of the 2019-nCoV, lacking in the other SARS-like CoVs. 

Furin is a "highly expressed" protein found in the lungs of humans that could have been used to activate a virus that previously could have only been passed between animals. The experts claimed this “peculiar furin” is an anomaly and could be used to “successfully exploit” enzymes that innate immunity in humans. It adds: “Before the emergence of the 2019-nCoV, this important feature was not observed in other coronaviruses."

The paper concludes that this part of the DNA chain has altered with a “gain-of-function to the 2019-nCoV for efficient spreading in the human population compared to other coronaviruses." 

Such 'gain of function' can be obtained through either genetic engineering or mutation. The paper did not amplify how the 'gain of function' for Coronavirus 2019 had occurred. It was therefore incorrect when our article claimed "Coronavirus shock claim: Virus 'genetically engineered for efficient spread in humans'. 

We are happy to set the record straight. 

Why US Outsourced Bat Virus Research to Wuhan: Greetings from Bruce Ivins

 ABSTRACT

 Why US Outsourced Bat Virus Research to Wuhan   [open pdf - 0B]

From the Abstract: "A U.S. NIH [National Institute of Health]-funded $3.7 million project was approved by Trump's Covid-19 [coronavirus disease 2019] advisor Dr. Anthony Fauci in 2015, after the Obama White House imposed a ban on 'monster-germ' research. In October 2014, the federal government declared a moratorium on gain-of-function research to weaponize viruses related to influenza, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). As a result, the research was outsourced to China's Wuhan Institute of Virology, which is currently at the center of scrutiny for the Covid-19 pandemic."

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1 Issue No. 689 April 2020 ISPSW Strategy Series: Focus on Defense and International Security Why US outsourced bat virus research to Wuhan Dr Christina Lin © Institut für Strategie- Politik- Sicherheits- und Wirtschaftsberatung ISPSW Giesebrechtstr. 9 Tel +49 (0)30 88 91 89 05 E-Mail: info@ispsw.de 10629 Berlin Fax +49 (0)30 88 91 89 06 Website: http://www.ispsw.de Germany Why US outsourced bat virus research to Wuhan Dr Christina Lin April 2020 Abstract A U.S. NIH-funded $3.7 million project was approved by Trump's Covid-19 advisor Dr. Anthony Fauci in 2015, after the Obama White House imposed a ban on 'monster-germ' research. In October 2014, the federal government declared a moratorium on gain-of-function research to weaponize viruses related to influenza, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). As a result, the research was outsourced to China’s Wuhan Institute of Virology, which is currently at the center of scrutiny for the Covid-19 pandemic. About ISPSW The Institute for Strategic, Political, Security and Economic Consultancy (ISPSW) is a private institute for research and consultancy. The ISPSW is an objective, task-oriented and politically non-partisan institute. In the ever more complex international environment of globalized economic processes and worldwide political, ecological, social and cultural change, which occasions both major opportunities and risks, decision-makers in the economic and political arena depend more than ever before on the advice of highly qualified experts. ISPSW offers a range of services, including strategic analyses, security consultancy, executive coaching and intercultural competency. ISPSW publications examine a wide range of topics connected with politics, the economy, international relations, and security/ defense. ISPSW network experts have worked – in some cases for decades – in executive positions and have at their disposal a wide range of experience in their respective fields of expertise. About the Author of this Issue Dr. Christina Lin is a California-based foreign policy analyst. She has extensive US government experience working on national security policy planning, including at DoD, State, and NSC, and was a research consultant at Jane’s Information Group’s Chemical, Biological, Radiological & Nuclear Assessments Intelligence Centre. Christina Lin 2 Issue No. 689 April 2020 ISPSW Strategy Series: Focus on Defense and International Security Why US outsourced bat virus research to Wuhan Dr Christina Lin © Institut für Strategie- Politik- Sicherheits- und Wirtschaftsberatung ISPSW Giesebrechtstr. 9 Tel +49 (0)30 88 91 89 05 E-Mail: info@ispsw.de 10629 Berlin Fax +49 (0)30 88 91 89 06 Website: http://www.ispsw.de Germany Analysis After a temporary détente between the US and China to put aside the blame game and cooperate to fight Covid19, it seems conspiracy theories are once again flaring up and sabotaging joint efforts to control the pandemic. The US National Institute of Health (NIH) funded bat coronavirus research in the Wuhan Institute of Virology to the tune of $3.7 million, a recent article in the British newspaper Daily Mail revealed.1 Back in October 2014, the US government had placed a federal moratorium on gain-of-function (GOF) research—altering natural pathogens to make them more deadly and infectious–as a result of rising fears about a possible pandemic caused by accidental or deliberate release of these genetically engineered monster germs.2 This was in part due to lab accidents at the US Centers for Disease Control and Prevention (CDC) in July 2014 that raised questions about biosafety at US high-containment labs.3 At that time, the CDC had closed two labs and halted some biological shipments in the wake of several incidents in which highly pathogenic microbes were mishandled by federal laboratories: an accidental shipment of live anthrax, the discovery of forgotten, live smallpox samples, and a newly revealed incident in which a dangerous influenza strain was accidentally shipped from CDC to another lab. A CDC internal report described how scientists failed to follow proper procedures to ensure samples were inactivated before they left the lab, and also found “multiple other problems” with operating procedures in the anthrax lab.4 As such in October 2014, due to public health concerns the US government banned all federal funding on efforts to weaponize three viruses—influenza, Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome (SARS).5 In the face of a moratorium in the US, Dr. Anthony Fauci–director of the National Institute of Allergy and Infectious Disease (NIAID) and currently the leading doctor in the US Coronavirus Task Force–outsourced in 2015 the GOF research to China’s Wuhan lab and licensed the lab to continue receiving federal funding.6 The Wuhan lab is now at the center of scrutiny for possibly releasing the SARS-CoV-2 coronavirus and causing the global Covid-19 pandemic. 1 Glen Own, “Wuhan lab was performing coronavirus experiments on bats from the caves where the disease is believed to have originated - with a £3m grant from the US“, Daily Mail, April 11, 2020, https://www.dailymail.co.uk/news/article-8211257/Wuhanlab-performing-experiments-bats-coronavirus-caves.html 2 Jocelyn Kaiser, David Malakoff, “U.S. halts funding for new risky virus studies, calls for voluntary moratorium”, Science Magazine, October 17, 2014, https://www.sciencemag.org/news/2014/10/us-halts-funding-new-risky-virus-studies-calls-voluntary-moratorium 3 Jocelyn Kaiser, “Lab incidents lead to safety crackdown at CDC”, Science Magazine, July 11, 2014, https://www.sciencemag.org/news/2014/07/lab-incidents-lead-safety-crackdown-cdc; Christina Lin, “Biosecurity in question at U.S. germ labs”, Asia Times, April 6, 2020, https://asiatimes.com/2020/04/biosecurity-in-question-at-us-germ-labs/ 4 U.S. Centers for Disease Control and Prevention, “CDC Director Releases After-Action Report on Recent Anthrax Incident; Highlights Steps to Improve Laboratory Quality and Safety”, CDC Press Release, July 11, 2014, https://www.cdc.gov/media/releases/2014/p0711-lab-safety.html 5 U.S. Public Health Emergency, “U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza, MERS, and SARS Viruses” October 17, 2014, http://www.phe.gov/s3/dualuse/Documents/gain-of-function.pdf 6 Patrick Howley, “Fauci’s NIAID Funded Wuhan Lab Scientists To Research Bat Coronavirus”, National File, April 13, 2020, https://nationalfile.com/faucis-niaid-funded-wuhan-lab-scientists-to-research-bat-coronavirus/; C-SPAN, “U.S. 2015 Grant to Wuhan Lab question”, April 18, 2020, https://www.c-span.org/video/?c4869590/user-clip-us-2015-grant-wuhan-lab-question; Charles Crietz, “Gaetz calls for end to NIH grant to Wuhan virology lab, says it can be done with 'stroke of a pen'”, Fox News, April 14, 2020, https://www.foxnews.com/media/gaetz-end-nih-grant-wuhan-virology-lab 3 Issue No. 689 April 2020 ISPSW Strategy Series: Focus on Defense and International Security Why US outsourced bat virus research to Wuhan Dr Christina Lin © Institut für Strategie- Politik- Sicherheits- und Wirtschaftsberatung ISPSW Giesebrechtstr. 9 Tel +49 (0)30 88 91 89 05 E-Mail: info@ispsw.de 10629 Berlin Fax +49 (0)30 88 91 89 06 Website: http://www.ispsw.de Germany Understandably, China’s lab would likely struggle with safety issues given the fact US labs also share similar problems, and indeed in January 2018 the US embassy in Beijing sent cables warning about safety of the Wuhan lab and asked for help.7 Additionally, the cable warned the researchers “showed that various SARS-like coronaviruses can interact with ACE2, the human receptor identified for SARS-coronavirus,” meaning bat coronaviruses can be transmitted to humans to cause SARS-like diseases. Now, the US is up in arms to hold China accountable for the global coronavirus pandemic, filing class action lawsuits domestically, as well as building a coalition with allies internationally.8 Lawsuits have been filed within the US and the International Criminal Court that China used the virus as a bioweapon, and other suits are underway at the International Court of Justice. GOP lawmakers such as Sen. Tom Cotton and Rep. Dan Crenshaw have also introduced legislation that would allow Americans to sue China in federal court over the death and economic damage wrought by the virus.9 US spy agencies are also investigating whether the virus originated in the Wuhan lab, and seeking evidence that is needed to support the bio WMD theory promoted by GOP lawmakers. If evidence is found that Covid-19 is a biological weapon, some pundits such as Fox News host Lou Dobbs have called for the US to declare war on China.10 Nonetheless, it is unclear what the legal ramifications would be if the virus is indeed leaked from a Chinese lab, but from a research project that was outsourced and funded by the US government. Also, if there is a government ban in 2014 on federal funding being used for GOF research, what are the federal compliance and ethical issues surrounding the fact that NIH still gave federal funding instead of private funding to the Wuhan lab to continue the experiments? Moreover, could some strains of the coronavirus originate in US labs, given the fact the US government lifted the ban in December 2017 on GOF research without resolving lab safety issues?11 7 Josh Rogin, “State Department cables warned of safety issues at Wuhan lab studying bat coronaviruses”, Washington Post, April 14, 2020, https://www.washingtonpost.com/opinions/2020/04/14/state-department-cables-warned-safety-issues-wuhan-lab-studying-batcoronaviruses/ 8 “Thousands sign up to U.S. class action to sue China over coronavirus”, MSN, April 20, 2020, https://www.msn.com/enxl/northamerica/northamerica-top-stories/thousands-sign-up-to-us-class-action-to-sue-china-over-coronavirus/arBB12Uqmp?li=BBJDXDP ; “World’s superpowers join forces against China over coronavirus’, April 20, 2020, https://iharare.com/worlds-superpowers-join-forces-against-china/ 9 Kevin Krause, “Lawsuit in Dallas federal court accuses Chinese government of creating coronavirus as ‘biological weapon’”, Dallas News, March 18, 2020, https://www.dallasnews.com/news/public-health/2020/03/18/dallas-federal-lawsuit-accuses-chinese-government-of-creatingcoronavirus-as-biological-weapon /; Joseph Young, “Bombshell ICC Complaint Sues China Over Alleged Coronavirus ‘Bioweapon’, CCN, April 2, 2020, https://www.ccn.com/bombshell-icc-complaint-sues-china-over-alleged-coronavirusbioweapon/ ; Yaron Steinbuch, “Lawmakers introduce bill that would let Americans sue China over ‘Wuhan Virus’”, New York Post, April 17, 2020, https://nypost.com/2020/04/17/lawmakers-introduce-bill-allowing-americans-to-sue-china-over-coronavirus/ 10 Jerry Dunleavy, “'Creating an accurate picture': US spy agencies investigating Wuhan lab escape coronavirus theory”, Washington Examiner, April 17, 2020,https://www.washingtonexaminer.com/news/creating-an-accurate-picture-us-spyagencies-investigating-wuhan-lab-escape-coronavirus-theory; Daragh Roche, “Fox’s Lou Dobbs Mulls War with China if Coronavirus Is “A Biological Weapon””, Politics USA, April 17, 2020, https://www.politicususa.com/2020/04/17/foxs-lou-dobbsmulls-war-with-china-if-coronavirus-is-a-biological-weapon.html ; Amelia Mayvis Christnot, “Fox Business Host Lou Dobbs Thinks The U.S. Should Go To War With China As A Consequence Of The Pandemic”, April 20, 2020, https://www.comicsands.com/china-conspiracy-theory-dobbs-fox-2645759264.html 11 Sara Reardon, “US government lifts ban on risky pathogen research”, Nature, December 19, 2017, https://www.nature.com/articles/d41586-017-08837-7 4 Issue No. 689 April 2020 ISPSW Strategy Series: Focus on Defense and International Security Why US outsourced bat virus research to Wuhan Dr Christina Lin © Institut für Strategie- Politik- Sicherheits- und Wirtschaftsberatung ISPSW Giesebrechtstr. 9 Tel +49 (0)30 88 91 89 05 E-Mail: info@ispsw.de 10629 Berlin Fax +49 (0)30 88 91 89 06 Website: http://www.ispsw.de Germany For now, the Trump administration is investigating the $3.7 million taxpayer money that went to the Wuhan lab, while Republican lawmaker Matt Gaetz called for an immediate end to NIH funding of Chinese research.12 Since the federal ban on GOF research has been lifted, US labs can continue creating these monster germs domestically and would no longer need to outsource to China. Nonetheless, there still needs to be better oversight on the dangerous experiments and regulations over biosecurity of labs. Currently, the National Science Advisory Board for Biosecurity (NSABB)—a US government interagency panel that advises the NIH’s parent, the US Department of Health and Human Services (HHS), conducts risk assessment of GOF experiments that pose a significant threat to public health.13 NSABB has given HHS a framework to assess proposed research that would create pathogens with pandemic potential, such as research on genetically altering a virus to infect more species, or recreating a pathogen that has been eradicated in the wild, such as smallpox. However, vaccine development and epidemiological surveillance do not automatically trigger the HHS review. In the post-mortem of the Covid-19 pandemic, this is likely a dangerous loophole that could be exploited with no oversight, and should probably be brought under HHS review in order to better protect public health in the future. *** Remarks: Opinions expressed in this contribution are those of the author. This article first appeared in Asia Times on April 22, 2020. 12 Shubhangi Shah, “Trump discusses Obama's $3.7 mln grant as Wuhan virology lab comes under intense scrutiny”, International Business Times, April 18, 2020, https://www.ibtimes.sg/trump-discusses-obamas-3-7-mln-grant-wuhan-virology-lab-comes-under-intense-scrutiny-videos-43261 Charles Crietz, “Gaetz calls for end to NIH grant to Wuhan virology lab, says it can be done with 'stroke of a pen'”, Fox News, April 14, 2020, https://www.foxnews.com/media/gaetz-end-nih-grant-wuhan-virology-lab 13 https://en.wikipedia.org/wiki/National_Science_Advisory_Board_for_Biosecurity

 

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