Patents by Inventor Ralph Baric

 

Patents by Inventor Ralph Baric

Ralph Baric has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

• Methods and compositions for dengue virus vaccines

  Patent number: 10870682

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Grant

  Filed: August 20, 2018

  Date of Patent: December 22, 2020

  Assignee: The University of North Carolina at Chapel Hill

  Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount

• METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT

  Publication number: 20200230224

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Application

  Filed: August 29, 2019

  Publication date: July 23, 2020

  Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom

• METHODS AND COMPOSITIONS FOR DENGUE VIRUS SEROTYPE 4 EPITOPES

  Publication number: 20200155663

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Application

  Filed: May 23, 2018

  Publication date: May 21, 2020

  Inventors: Ralph BARIC, Matthew BEGLEY, Douglas WIDMAN, Aravinda DESILVA, Usha NIVARTHI, Boyd YOUNT, Ellen YOUNG

• Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development

  Patent number: 10398768

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Grant

  Filed: November 2, 2015

  Date of Patent: September 3, 2019

  Assignee: The University of North Carolina at Chapel Hill

  Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom

• METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES

  Publication number: 20190225654

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Application

  Filed: August 20, 2018

  Publication date: July 25, 2019

  Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount

• METHODS AND COMPOSITIONS FOR ZIKA VIRUS VACCINES

  Publication number: 20190023745

  Abstract: The present invention methods and compositions for treating a Zika virus infection in a subject, comprising administering to the subject an effective amount of an antibody against Zika virus and/or an epitope that induces an immune response to Zika virus.

  Type: Application

  Filed: July 19, 2018

  Publication date: January 24, 2019

  Inventors: Ralph Baric, Jessica A. Plante, Jesica Swanstrom, Matthew Begley

• Methods and compositions for dengue virus vaccines

  Patent number: 10053493

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Grant

  Filed: June 26, 2014

  Date of Patent: August 21, 2018

  Assignee: The University of North Carolina at Chapel Hill

  Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount

• Methods and compositions for chimeric coronavirus spike proteins

  Patent number: 9884895

  Abstract: The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.

  Type: Grant

  Filed: March 20, 2015

  Date of Patent: February 6, 2018

  Assignee: The University of North Carolina at Chapel Hill

  Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount

• METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT

  Publication number: 20170333548

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Application

  Filed: November 2, 2015

  Publication date: November 23, 2017

  Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom

• METHODS AND COMPOSITIONS FOR CHIMERIC CORONAVIRUS SPIKE PROTEINS

  Publication number: 20170096455

  Abstract: The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.

  Type: Application

  Filed: March 20, 2015

  Publication date: April 6, 2017

  Applicant: The University of North Carolina at Chapel Hill

  Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount

• Methods and Compositions for Dengue Virus Vaccines

  Publication number: 20160257719

  Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

  Type: Application

  Filed: June 26, 2014

  Publication date: September 8, 2016

  Inventors: William MESSER, Ralph BARIC, Aravinda DE SILVA, Boyd YOUNT

• METHODS AND COMPOSITIONS FOR CORONAVIRUS DIAGNOSTICS AND THERAPEUTICS

  Publication number: 20160238601

  Abstract: The present invention provides methods and compositions for detecting a coronavirus in a sample and identifying the subgroup of the coronavirus in the sample.

  Type: Application

  Filed: October 14, 2014

  Publication date: August 18, 2016

  Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount

• Methods and compositions for infectious cDNA of SARS coronavirus

  Publication number: 20060240530

  Abstract: The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus, recombinant SARS coronavirus vectors, and SARS coronavirus replicon particles. Also provided are methods of making the compositions of this invention and methods of using the compositions as immunogens and/or vaccines and/or to express heterologous nucleic acids.

  Type: Application

  Filed: January 19, 2006

  Publication date: October 26, 2006

  Inventors: Ralph Baric, Rhonda Roberts, Boyd Yount, Kristopher Curtis